Ankylosing Spondylitis
Expert diagnosis and personalized treatment at Arthritis Care of Los Angeles.
What is Ankylosing Spondylitis?
Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints (where the spine meets the pelvis). Over time, the inflammation can cause some of the vertebrae in the spine to fuse together, leading to reduced flexibility and a hunched posture. AS can also affect other joints, tendons, and even the eyes. It typically begins in early adulthood and is more common in men. Early diagnosis and treatment are important to maintain mobility and prevent spinal fusion.
Common Symptoms
- Chronic lower back pain and stiffness, worse in the morning
- Pain that improves with exercise but not with rest
- Stiffness and reduced flexibility in the spine
- Pain at the base of the spine (sacroiliac joints)
- Fatigue
- Pain in the hips, shoulders, or ribs
- Inflammation of the eyes (iritis/uveitis)
- Difficulty taking deep breaths if rib joints are affected
Experiencing these symptoms? Get expert care today.
How is Ankylosing Spondylitis Diagnosed?
Diagnosis involves physical examination assessing spinal mobility, blood tests (HLA-B27 gene and inflammatory markers), and imaging studies. MRI of the sacroiliac joints can detect early inflammation before changes appear on X-rays. Dr. Forouzesh recognizes that AS is often underdiagnosed, with patients waiting an average of 7 years for a correct diagnosis. He takes a thorough approach to identify AS early.
Treatment Options
Biologic Therapies
TNF inhibitors and IL-17 inhibitors are highly effective at controlling inflammation and preventing spinal fusion in AS.
NSAIDs
Anti-inflammatory medications that are often the first-line treatment for pain and stiffness in AS.
Physical Therapy
Regular stretching and strengthening exercises are essential to maintain spinal flexibility and posture. This is a core part of AS management.
JAK Inhibitors
Newer oral medications that target inflammatory pathways and can be effective for patients who do not respond to other treatments.
Posture Training
Techniques and exercises focused on maintaining good posture and preventing the forward curvature that can develop over time.
Key Statistics
2.7 Million
Americans estimated to have AS or axial spondyloarthritis
Source: Spondylitis Association of America
7 Years
Average delay from symptoms to diagnosis
Source: American College of Rheumatology
17-45
Typical age of onset (years)
Source: NIH/NIAMS
Frequently Asked Questions
Ready to Get Expert Care?
Schedule your appointment with Dr. Solomon Forouzesh, MD, FACP, FACR — a board-certified rheumatologist with 50++ years of expertise in arthritis and autoimmune diseases.